Dose-Dependent Resorption of Quinine after Intrarectal Administration to Children with Moderate Plasmodium falciparum Malaria

The pharmacokinetics of increasing doses of an intrarectal Cinchona alkaloid combination containing 96.1% quinine, 2.5% quinidine, 0.68% cinchonine, and 0.67% cinchonidine (Quinimax) was compared to that of parenteral regimens in 60 children with moderate malaria. Quinine exhibited a nonlinear pharm...

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Detalhes bibliográficos
Main Authors: Pussard, Eric, Straczek, Celine, Kaboré, Idrissa, Bicaba, Auguste, Balima-Koussoube, Tatiana, Bouree, Patrice, Barennes, Hubert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC525409/
https://ncbi.nlm.nih.gov/pubmed/15504872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.11.4422-4426.2004
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