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Fluid shear stress activates YAP1 to promote cancer cell motility
Mechanical stress is pervasive in egress routes of malignancy, yet the intrinsic effects of force on tumour cells remain poorly understood. Here, we demonstrate that frictional force characteristic of flow in the lymphatics stimulates YAP1 to drive cancer cell migration; whereas intensities of fluid...
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| Vydáno v: | Nat Commun |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5253685/ https://ncbi.nlm.nih.gov/pubmed/28098159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14122 |
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