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Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway

Many positive signalling pathways of osteoclastogenesis have been characterized, but negative signalling pathways are less well studied. Here we show by microarray and RNAi that guanine nucleotide-binding protein subunit α13 (Gα13) is a negative regulator of osteoclastogenesis. Osteoclast-lineage-sp...

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Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Wu, Mengrui, Chen, Wei, Lu, Yun, Zhu, Guochun, Hao, Liang, Li, Yi-Ping
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253683/
https://ncbi.nlm.nih.gov/pubmed/28102206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13700
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