MET exon 14 juxtamembrane splicing mutations: clinical and therapeutical perspectives for cancer therapy

The MET proto-oncogene plays crucial roles in cell growth and proliferation, survival and apoptosis, epithelial-mesenchymal transition (EMT) and invasion, potentially conditioning the development and progression of the carcinogenesis process. The MET-associated aberrant signaling could be triggered...

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Bibliographic Details
Published in:Ann Transl Med
Main Authors: Pilotto, Sara, Gkountakos, Anastasios, Carbognin, Luisa, Scarpa, Aldo, Tortora, Giampaolo, Bria, Emilio
Format: Artigo
Language:Inglês
Published: AME Publishing Company 2017
Subjects:
Review Article on MET as Actionable Target in Cancer Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253296/
https://ncbi.nlm.nih.gov/pubmed/28164087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2016.12.33
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