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Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?
The occurrence of high rates of somatic mutations in cancer is believed to correspond to increased frequency of neo-epitope formation and tumor immunogenicity. Thus, classification of patients with cancer according to degree a somatic hyper-mutational status could be proposed as a predictive biomark...
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| Publicado no: | J Transl Med |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5251272/ https://ncbi.nlm.nih.gov/pubmed/28109293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1119-6 |
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