Phosphodiesterase-5 inhibition suppresses colonic inflammation-induced tumorigenesis via blocking the recruitment of MDSC

Phosphodiesterase 5 (PDE-5) is a major isoform of cGMP phosphodiesterase in diverse tissues and plays a critical role in regulating intracellular cGMP concentrations. However, the distribution and expression of PDE-5 in colitis-related colon cancer was still unclear, not even the function and mechan...

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Vydáno v:Am J Cancer Res
Hlavní autoři: Lin, Shiyong, Wang, Jing, Wang, Lihui, Wen, Jing, Guo, Yandong, Qiao, Weiguang, Zhou, Jieqiong, Xu, Guoliang, Zhi, Fachao
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5250679/
https://ncbi.nlm.nih.gov/pubmed/28123846
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