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Life and death in the trash heap: the ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia
The ubiquitin proteasome pathway (UPP) is essential for removing abnormal proteins and preventing accumulation of potentially toxic proteins within the neuron. UPP dysfunction occurs with normal aging and is associated with abnormal accumulation of protein aggregates within neurons in neurodegenerat...
Shranjeno v:
| izdano v: | Ageing Res Rev |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5250550/ https://ncbi.nlm.nih.gov/pubmed/27702698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.arr.2016.09.011 |
| Oznake: |
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