Sequence Variation within the Dominant Amino Terminus Epitope Affects Antibody Binding and Neutralization of Human Immunodeficiency Virus Type 1 Tat Protein

Tat is among the required regulatory genes of human immunodeficiency virus type 1 (HIV-1). Tat functions both within infected cells as a transcription factor and as an extracellular factor that binds and alters bystander cells. Some functions of extracellular Tat can be neutralized by immune serum o...

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Autors principals: Ruckwardt, Tracy J., Tikhonov, Ilia, Berg, Shannon, Hatfield, Glen S., Chandra, Angelika, Chandra, Prakash, Gilliam, Bruce, Redfield, Robert R., Gallo, Robert C., Pauza, C. David
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC524972/
https://ncbi.nlm.nih.gov/pubmed/15542671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.23.13190-13196.2004
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