Characterization of a Broadly Reactive Anti-CD40 Agonistic Monoclonal Antibody for Potential Use as an Adjuvant

Lack of safe and effective adjuvants is a major hindrance to the development of efficacious vaccines. Signaling via CD40 pathway leads to enhanced antigen processing and presentation, nitric oxide expression, pro-inflammatory cytokine expression by antigen presenting cells, and stimulation of B-cell...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Martin, Cameron, Waghela, Suryakant D., Lokhandwala, Shehnaz, Ambrus, Andy, Bray, Jocelyn, Vuong, Christina, Vinodkumar, Vanitha, Dominowski, Paul J., Rai, Sharath, Mwangi, Duncan, Foss, Dennis L., Mwangi, Waithaka
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5249191/
https://ncbi.nlm.nih.gov/pubmed/28107431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170504
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