Tanshinone IIA induces intrinsic apoptosis in osteosarcoma cells both in vivo and in vitro associated with mitochondrial dysfunction

Tanshinone IIA (Tan IIA), a phytochemical derived from the roots of Salvia miltiorrhiza, has been shown to inhibit growth and induce apoptosis in various cancer cells. The association of its inhibitory effect on the primary malignant bone tumor, osteosarcoma, with mitochondrial dysfunction remains u...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Huang, Sheng-Teng, Huang, Chao-Chun, Huang, Wen-Liang, Lin, Tsu-Kung, Liao, Pei-Lin, Wang, Pei-Wen, Liou, Chia-Wei, Chuang, Jiin-Haur
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247764/
https://ncbi.nlm.nih.gov/pubmed/28106052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40382
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