Effects of IL-4 on Pulmonary Fibrosis and the Accumulation and Phenotype of Macrophage Subpopulations Following Thoracic Irradiation

PURPOSE: Thoracic irradiation injures lung parenchyma, triggering inflammation and immune cell activation, leading to pneumonitis and fibrosis. Macrophage polarization contributes to these processes. Since IL-4 promotes pro-fibrotic macrophage activation, its role in radiation-induced lung injury wa...

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Vydáno v:Int J Radiat Biol
Hlavní autoři: Groves, Angela M., Johnston, Carl J., Misra, Ravi S., Williams, Jacqueline P., Finkelstein, Jacob N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247271/
https://ncbi.nlm.nih.gov/pubmed/27539247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/09553002.2016.1222094
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