Renal targeting potential of a polymeric drug carrier, poly-l-glutamic acid, in normal and diabetic rats

BACKGROUND AND PURPOSE: Poly-l-glutamic acid (PG) has been used widely as a carrier to deliver anticancer chemotherapeutics. This study evaluates PG as a selective renal drug carrier. EXPERIMENTAL APPROACH: (3)H-deoxycytidine-labeled PGs (17 or 41 kDa) and (3)H-deoxycytidine were administered intrav...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Int J Nanomedicine
Hauptverfasser: Chai, Hann-Juang, Kiew, Lik-Voon, Chin, Yunni, Norazit, Anwar, Mohd Noor, Suzita, Lo, Yoke-Lin, Looi, Chung-Yeng, Lau, Yeh-Siang, Lim, Tuck-Meng, Wong, Won-Fen, Abdullah, Nor Azizan, Abdul Sattar, Munavvar Zubaid, Johns, Edward J, Chik, Zamri, Chung, Lip-Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2017
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5245978/
https://ncbi.nlm.nih.gov/pubmed/28144140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S111284
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