Splenic CD4(+) T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through Inhibitory Receptor Expression

Visceral leishmaniasis (VL), caused by infection with the intracellular protozoan Leishmania donovani, is a chronic progressive disease with a relentlessly increasing parasite burden in the spleen, liver and bone marrow. The disease is characterized by fever, splenomegaly, cachexia, and pancytopenia...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Medina-Colorado, Audrie A., Osorio, Elvia Y., Saldarriaga, Omar A., Travi, Bruno L., Kong, Fanping, Spratt, Heidi, Soong, Lynn, Melby, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5245871/
https://ncbi.nlm.nih.gov/pubmed/28103263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169496
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