A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma

PURPOSE: This pilot feasibility clinical trial evaluated the co-administration of vemurafenib, a small molecule antagonist of BRAF(V600) mutations, and tumor infiltrating lymphocytes (TIL) for the treatment of metastatic melanoma. EXPERIMENTAL DESIGN: A metastatic tumor was resected for growth of TI...

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Pubblicato in:Clin Cancer Res
Autori principali: Deniger, Drew C., Kwong, Mei Li M., Pasetto, Anna, Dudley, Mark E., Wunderlich, John R., Langhan, Michelle M., Lee, Chyi-Chia Richard, Rosenberg, Steven A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5245178/
https://ncbi.nlm.nih.gov/pubmed/28093487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-0906
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