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Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D(3 )receptor
BACKGROUND: Our aim was to determine if pramipexole, a D(3 )preferring agonist, effectively reduced dopamine neuron and fiber loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model when given at intraperitoneal doses corresponding to clinical doses. We also determined whether su...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2004
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC524509/ https://ncbi.nlm.nih.gov/pubmed/15473914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-2-22 |
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