Host knockout of E-prostanoid 2 receptors reduces tumor growth and causes major alterations of gene expression in prostaglandin E(2)-producing tumors

Prostaglandin E(2) (PGE(2)) is elevated in a variety of malignant tumors and has been shown to affect several hallmarks of cancer. Accordingly, the PGE(2) receptor, E-prostanoid 2 (EP2), has been reported to be associated with patient survival and reduced tumor growth in EP2-knockout mice. Thus, the...

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Publicado en:Oncol Lett
Autores principales: Asting, Annika Gustafsson, Iresjö, Britt-Marie, Nilsberth, Camilla, Smedh, Ulrika, Lundholm, Kent
Formato: Artigo
Lenguaje:Inglês
Publicado: D.A. Spandidos 2017
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5244965/
https://ncbi.nlm.nih.gov/pubmed/28123585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2016.5448
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