HO-1 inhibits preadipocyte proliferation and differentiation at the onset of obesity via ROS dependent activation of Akt2

Excessive accumulation of white adipose tissue (WAT) is a hallmark of obesity. The expansion of WAT in obesity involves proliferation and differentiation of adipose precursors, however, the underlying molecular mechanisms remain unclear. Here, we used an unbiased transcriptomics approach to identify...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Wagner, Gabriel, Lindroos-Christensen, Josefine, Einwallner, Elisa, Husa, Julia, Zapf, Thea-Christin, Lipp, Katharina, Rauscher, Sabine, Gröger, Marion, Spittler, Andreas, Loewe, Robert, Gruber, Florian, Duvigneau, J. Catharina, Mohr, Thomas, Sutterlüty-Fall, Hedwig, Klinglmüller, Florian, Prager, Gerhard, Huppertz, Berthold, Yun, Jeanho, Wagner, Oswald, Esterbauer, Harald, Bilban, Martin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5244367/
https://ncbi.nlm.nih.gov/pubmed/28102348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40881
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