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Predicting Drug Combination Index and Simulating the Network-Regulation Dynamics by Mathematical Modeling of Drug-Targeted EGFR-ERK Signaling Pathway

Synergistic drug combinations enable enhanced therapeutics. Their discovery typically involves the measurement and assessment of drug combination index (CI), which can be facilitated by the development and applications of in-silico CI predictive tools. In this work, we developed and tested the abili...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Huang, Lu, Jiang, Yuyang, Chen, Yuzong
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5244366/
https://ncbi.nlm.nih.gov/pubmed/28102344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40752
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