IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase

Signalling by cGMP-dependent protein kinase type I (cGKI) relaxes various smooth muscles modulating thereby vascular tone and gastrointestinal motility. cGKI-dependent relaxation is possibly mediated by phosphorylation of the inositol 1,4,5-trisphosphate receptor I (IP(3)RI)-associated protein (IRAG...

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Hauptverfasser: Geiselhöringer, Angela, Werner, Matthias, Sigl, Katja, Smital, Petra, Wörner, René, Acheo, Linda, Stieber, Juliane, Weinmeister, Pascal, Feil, Robert, Feil, Susanne, Wegener, Jörg, Hofmann, Franz, Schlossmann, Jens
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC524403/
https://ncbi.nlm.nih.gov/pubmed/15483626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600440
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