Cell-line-induced mutation of the rotavirus genome alters expression of an IRF3-interacting protein

Rotavirus, a cause of severe gastroenteritis, contains a segmented double-stranded (ds)RNA genome that replicates using viral mRNAs as templates. The highly conserved 3′-consensus sequence (3′CS), UGUGACC, of the mRNAs promotes dsRNA synthesis and enhances translation. We have found that the 3′CS of...

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Main Authors: Kearney, Karen, Chen, Dayue, Taraporewala, Zenobia F, Vende, Patrice, Hoshino, Yasutaka, Tortorici, Maria Alejandra, Barro, Mario, Patton, John T
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC524342/
https://ncbi.nlm.nih.gov/pubmed/15372078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600408
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