Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer

The lethal phenotype of castration-resistant prostate cancer (CRPC) is generally caused by augmented signaling from the androgen receptor (AR). Here we report that the AR-repressed gene CCN3/NOV inhibits AR signaling and acts in a negative feedback loop to block AR function. Mechanistically, a cytop...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Fong, Ka-wing, Zhao, Jonathan C., Kim, Jung, Li, Shangze, Yang, Yeqing Angela, Song, Bing, Rittie, Laure, Hu, Ming, Yang, Ximing, Perbal, Bernard, Yu, Jindan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5243151/
https://ncbi.nlm.nih.gov/pubmed/27815387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1949
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