Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer

The lethal phenotype of castration-resistant prostate cancer (CRPC) is generally caused by augmented signaling from the androgen receptor (AR). Here we report that the AR-repressed gene CCN3/NOV inhibits AR signaling and acts in a negative feedback loop to block AR function. Mechanistically, a cytop...

詳細記述

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書誌詳細
出版年:Cancer Res
主要な著者: Fong, Ka-wing, Zhao, Jonathan C., Kim, Jung, Li, Shangze, Yang, Yeqing Angela, Song, Bing, Rittie, Laure, Hu, Ming, Yang, Ximing, Perbal, Bernard, Yu, Jindan
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5243151/
https://ncbi.nlm.nih.gov/pubmed/27815387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1949
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