Astrocyte scar formation aids CNS axon regeneration

Transected axons fail to regrow in the mature central nervous system (CNS). Astrocyte scars are widely regarded as causal in this failure. Here, using three genetically targeted loss-of-function manipulations in adult mice, we show that preventing astrocyte scar formation, attenuating scar-forming a...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Anderson, Mark A., Burda, Joshua E., Ren, Yilong, Ao, Yan, O’Shea, Timothy M., Kawaguchi, Riki, Coppola, Giovanni, Khakh, Baljit S., Deming, Timothy J., Sofroniew, Michael V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5243141/
https://ncbi.nlm.nih.gov/pubmed/27027288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17623
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