Mutually exclusive recombination of wild-type and mutant loxP sites in vivo facilitates transposon-mediated deletions from both ends of genomic DNA in PACs

Recombination of wild-type and mutant loxP sites mediated by wild-type Cre protein was analyzed in vivo using a sensitive phage P1 transduction assay. Contrary to some earlier reports, recombination between loxP sites was found to be highly specific: a loxP site recombined in vivo only with another...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Chatterjee, Pradeep K., Shakes, Leighcraft A., Srivastava, Deepak K., Garland, Douglas M., Harewood, Ken R., Moore, Kyle J., Coren, Jonathon S.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2004
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC524307/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15494454/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh900
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