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Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells

BACKGROUND AND PURPOSE: Clemizole, a histamine H(1) receptor antagonist has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels. The aim of the present study was to investigate whether clemizole blocks cardiac K(+) currents and thus affects cardiac r...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Jie, Ling‐Jun, Wu, Wei‐Yin, Li, Gang, Xiao, Guo‐Sheng, Zhang, Shetuan, Li, Gui‐Rong, Wang, Yan
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241390/
https://ncbi.nlm.nih.gov/pubmed/27886373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13679
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