IL-21 enhances natural killer cell response to cetuximab-coated pancreatic tumor cells

PURPOSE: Alternative strategies to EGFR blockage by mAbs is necessary in order to improve the efficacy of therapy in patients with locally advanced or metastatic pancreatic cancer. One such strategy includes the use of NK cells to clear cetuximab-coated tumor cells, as need for novel therapeutic app...

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Publié dans:Clin Cancer Res
Auteurs principaux: McMichael, Elizabeth L., Jaime-Ramirez, Alena Cristina, Guenterberg, Kristan D., Luedke, Eric, Atwal, Lakhvir S., Campbell, Amanda R., Hu, Zhiwei, Tatum, Armika S., Kondadasula, Sri Vidya, Mo, Xiaokui, Tridandapani, Susheela, Bloomston, Mark, Ellison, E. Christopher, Williams, Terence M., Bekaii-Saab, Tanios, Carson, William E.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241232/
https://ncbi.nlm.nih.gov/pubmed/27435400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-0004
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