Structural and Molecular Basis for Ebola Virus Neutralization by Protective Human Antibodies

Ebola virus causes hemorrhagic fever with a high mortality rate and for which there is no approved therapy. Two human monoclonal antibodies, mAb100 and mAb114, in combination protect non-human primates against all signs of Ebola virus disease, including viremia. Here, we demonstrate that mAb100 reco...

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Publicado no:Science
Main Authors: Misasi, John, Gilman, Morgan S.A., Kanekiyo, Masaru, Gui, Miao, Cagigi, Alberto, Mulangu, Sabue, Corti, Davide, Ledgerwood, Julie E., Lanzavecchia, Antonio, Cunningham, James, Muyembe-Tamfun, Jean Jacques, Baxa, Ulrich, Graham, Barney S., Xiang, Ye, Sullivan, Nancy J., McLellan, Jason S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241105/
https://ncbi.nlm.nih.gov/pubmed/26917592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad6117
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