Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies

Large-scale genome-wide association results are typically obtained from a fixed-effects meta-analysis of GWAS summary statistics from multiple studies spanning different regions and/or time periods. This approach averages the estimated effects of genetic variants across studies. In case genetic effe...

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Vydáno v:PLoS Genet
Hlavní autoři: de Vlaming, Ronald, Okbay, Aysu, Rietveld, Cornelius A., Johannesson, Magnus, Magnusson, Patrik K. E., Uitterlinden, André G., van Rooij, Frank J. A., Hofman, Albert, Groenen, Patrick J. F., Thurik, A. Roy, Koellinger, Philipp D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240919/
https://ncbi.nlm.nih.gov/pubmed/28095416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006495
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