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Systems pharmacology and enhanced pharmacodynamic models for understanding antibody-based drug action and toxicity

Pharmacokinetic (PK) and pharmacodynamic (PD) models seek to describe the temporal pattern of drug exposures and their associated pharmacological effects produced at micro- and macro-scales of organization. Antibody-based drugs have been developed for a large variety of diseases, with effects exhibi...

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Vydáno v:MAbs
Hlavní autoři: Ait-Oudhia, Sihem, Ovacik, Meric Ayse, Mager, Donald E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240652/
https://ncbi.nlm.nih.gov/pubmed/27661132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1238995
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