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Genetic variant rs3750625 in the 3′UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site

α2A adrenergic receptor (α2A-AR) activation has been shown in animal models to play an important role in regulating the balance of acute pain inhibition vs. facilitation after both physical and psychological stress. To our knowledge the influence of genetic variants in the gene encoding α2A-AR, ADRA...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: Linnstaedt, Sarah D., Walker, Margaret G., Riker, Kyle D., Nyland, Jennifer E., Hu, JunMei, Rossi, Catherine, Swor, Robert A., Jones, Jeffrey S., Diatchenko, Luda, Bortsov, Andrey V., Peak, David A., McLean, Samuel A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239739/
https://ncbi.nlm.nih.gov/pubmed/27805929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000742
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