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P300 inhibition enhances gemcitabine-induced apoptosis of pancreatic cancer
The transcriptional cofactor p300 has histone acetyltransferase activity (HAT) and has been reported to participate in chromatin remodeling and DNA repair. We hypothesized that targeting p300 can enhance the cytotoxicity of gemcitabine, which induces pancreatic cancer cell apoptosis by damaging DNA....
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| Publicado en: | Oncotarget |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5239476/ https://ncbi.nlm.nih.gov/pubmed/27322077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10117 |
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