Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases

[Image: see text] The delta isoform of the phosphatidylinositol 3-kinase (PI3Kδ) has been shown to have an essential role in specific immune cell functions and thus represents a potential therapeutic target for autoimmune and inflammatory diseases. Herein, the optimization of a series of pyrrolotria...

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Foilsithe in:ACS Med Chem Lett
Main Authors: Erra, Montse, Taltavull, Joan, Gréco, Angelique, Bernal, Francisco Javier, Caturla, Juan Francisco, Gràcia, Jordi, Domínguez, María, Sabaté, Mar, Paris, Stéphane, Soria, Salomé, Hernández, Begoña, Armengol, Clara, Cabedo, Judit, Bravo, Mónica, Calama, Elena, Miralpeix, Montserrat, Lehner, Martin D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2016
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238472/
https://ncbi.nlm.nih.gov/pubmed/28105286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00438
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