Combination of Everolimus with Sorafenib for Solid Renal Tumors in Tsc2(+/−) Mice Is Superior to Everolimus Alone()

Tuberous sclerosis (TSC) is an inherited tumor syndrome caused by mutations in TSC1 or TSC2 that lead to aberrant activation of mTOR and development of tumors in multiple organs including the kidneys. The mTOR inhibitors rapamycin and everolimus (rapalogs) have demonstrated clinical efficacy in trea...

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Publicado en:Neoplasia
Main Authors: Yang, Jian, Samsel, Paulina A., Narov, Kalin, Jones, Ashley, Gallacher, Daniel, Gallacher, John, Sampson, Julian R., Shen, Ming Hong
Formato: Artigo
Idioma:Inglês
Publicado: Neoplasia Press 2017
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Original article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238457/
https://ncbi.nlm.nih.gov/pubmed/28092822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2016.12.008
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