Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic

The β-lactam antibiotic temocillin (6-α-methoxy-ticarcillin) shows stability to most extended spectrum β-lactamases, but is considered inactive against Pseudomonas aeruginosa. Mutations in the MexAB-OprM efflux system, naturally occurring in cystic fibrosis (CF) isolates, have been previously shown...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chalhoub, Hussein, Pletzer, Daniel, Weingart, Helge, Braun, Yvonne, Tunney, Michael M., Elborn, J. Stuart, Rodriguez-Villalobos, Hector, Plésiat, Patrick, Kahl, Barbara C., Denis, Olivier, Winterhalter, Mathias, Tulkens, Paul M., Van Bambeke, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238406/
https://ncbi.nlm.nih.gov/pubmed/28091521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40208
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