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Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif.

The Rev protein of human immunodeficiency virus type 1 is a sequence-specific RNA binding protein that is essential for viral replication. Here we present evidence that Rev is a stable oligomer both in vitro and in vivo. Analysis of Rev mutants indicates that oligomerization is essential for RNA bin...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Zapp, M L, Hope, T J, Parslow, T G, Green, M R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52377/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1715576/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.17.7734
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