RNA Sequencing Reveals that Kaposi Sarcoma-Associated Herpesvirus Infection Mimics Hypoxia Gene Expression Signature

Kaposi sarcoma-associated herpesvirus (KSHV) causes several tumors and hyperproliferative disorders. Hypoxia and hypoxia-inducible factors (HIFs) activate latent and lytic KSHV genes, and several KSHV proteins increase the cellular levels of HIF. Here, we used RNA sequencing, qRT-PCR, Taqman assays,...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Viollet, Coralie, Davis, David A., Tekeste, Shewit S., Reczko, Martin, Ziegelbauer, Joseph M., Pezzella, Francesco, Ragoussis, Jiannis, Yarchoan, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234848/
https://ncbi.nlm.nih.gov/pubmed/28046107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006143
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