Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial

BACKGROUND: There is high medical need for safe long-term immunosuppression monotherapy in kidney transplantation. Selective targeting of post-transplant alloantigen-(re)activated effector-T cells by anti-TNF antibodies after global T cell depletion may allow safe drug minimization, however, it is u...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Viklicky, Ondrej, Hruba, Petra, Tomiuk, Stefan, Schmitz, Sabrina, Gerstmayer, Bernhard, Sawitzki, Birgit, Miqueu, Patrick, Mrazova, Petra, Tycova, Irena, Svobodova, Eva, Honsova, Eva, Janssen, Uwe, Volk, Hans-Dieter, Reinke, Petra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234822/
https://ncbi.nlm.nih.gov/pubmed/28085915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169624
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