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Targeting a binding pocket within the trimer-of-hairpins: Small-molecule inhibition of viral fusion
Trimeric class I virus fusion proteins undergo a series of conformational rearrangements that leads to the association of C- and N-terminal heptad repeat domains in a “trimer-of-hairpins” structure, facilitating the apposition of viral and cellular membranes during fusion. This final fusion hairpin...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC523459/ https://ncbi.nlm.nih.gov/pubmed/15469910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406696101 |
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