Targeting a binding pocket within the trimer-of-hairpins: Small-molecule inhibition of viral fusion

Trimeric class I virus fusion proteins undergo a series of conformational rearrangements that leads to the association of C- and N-terminal heptad repeat domains in a “trimer-of-hairpins” structure, facilitating the apposition of viral and cellular membranes during fusion. This final fusion hairpin...

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Main Authors: Cianci, Christopher, Langley, David R., Dischino, Douglas D., Sun, Yaxiong, Yu, Kuo-Long, Stanley, Anne, Roach, Julia, Li, Zhufang, Dalterio, Richard, Colonno, Richard, Meanwell, Nicholas A., Krystal, Mark
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC523459/
https://ncbi.nlm.nih.gov/pubmed/15469910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406696101
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