Human Cytomegalovirus DNA Replication Requires Transcriptional Activation via an IE2- and UL84-Responsive Bidirectional Promoter Element within oriLyt

Amplification of the human cytomegalovirus (HCMV) lytic origin (oriLyt) in human fibroblasts is dependent upon six core replication proteins and UL84, IE2, and UL36-38. Using a telomerase-immortalized human fibroblast cell line (T-HFs), oriLyt-dependent DNA replication no longer required the gene pr...

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Pubblicato in:	J Virol
Autori principali:	Xu, Yiyang, Cei, Sylvia A., Huete, Alicia Rodriguez, Colletti, Kelly S., Pari, Gregory S.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2004
Soggetti:	Replication
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC523242/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15479808/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.21.11664-11677.2004
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