Human Cytomegalovirus DNA Replication Requires Transcriptional Activation via an IE2- and UL84-Responsive Bidirectional Promoter Element within oriLyt

Amplification of the human cytomegalovirus (HCMV) lytic origin (oriLyt) in human fibroblasts is dependent upon six core replication proteins and UL84, IE2, and UL36-38. Using a telomerase-immortalized human fibroblast cell line (T-HFs), oriLyt-dependent DNA replication no longer required the gene pr...

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Hlavní autoři: Xu, Yiyang, Cei, Sylvia A., Huete, Alicia Rodriguez, Colletti, Kelly S., Pari, Gregory S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC523242/
https://ncbi.nlm.nih.gov/pubmed/15479808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.21.11664-11677.2004
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