GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels

GsMTx4 is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs). It has six lysine residues that have been proposed to affect membrane binding. We synthesized six analogs with single lysine-to-glutamate substitutions and tested them against Piezo1 channels in outside-out pat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biophys J
Prif Awduron: Gnanasambandam, Radhakrishnan, Ghatak, Chiranjib, Yasmann, Anthony, Nishizawa, Kazuhisa, Sachs, Frederick, Ladokhin, Alexey S., Sukharev, Sergei I., Suchyna, Thomas M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2017
Pynciau:
Proteins
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5231890/
https://ncbi.nlm.nih.gov/pubmed/28076814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.11.013
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