Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus

We have developed genetically modified Ae. aegypti mosquitoes that activate the conserved antiviral JAK/STAT pathway in the fat body tissue, by overexpressing either the receptor Dome or the Janus kinase Hop by the blood feeding-induced vitellogenin (Vg) promoter. Transgene expression inhibits infec...

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Udgivet i:PLoS Negl Trop Dis
Main Authors: Jupatanakul, Natapong, Sim, Shuzhen, Angleró-Rodríguez, Yesseinia I., Souza-Neto, Jayme, Das, Suchismita, Poti, Kristin E., Rossi, Shannan L., Bergren, Nicholas, Vasilakis, Nikos, Dimopoulos, George
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5230736/
https://ncbi.nlm.nih.gov/pubmed/28081143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005187
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