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Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5(-/-) mice
Netherton syndrome (NS) is a human autosomal recessive skin disease caused by mutations in the SPINK5 gene, which encodes the putative proteinase inhibitor LEKTI. We have generated a transgenic mouse line with an insertional mutation that inactivated the mouse SPINK5 ortholog. Mutant mice exhibit fr...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC522985/ https://ncbi.nlm.nih.gov/pubmed/15466487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1232104 |
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