Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by an intense fibrotic stromal response and deregulated metabolism(1–4). The role of the stroma in PDAC biology is complex and it has been shown to play critical roles that differ depending on the biological context(5–10)...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Sousa, Cristovão M., Biancur, Douglas E., Wang, Xiaoxu, Halbrook, Christopher J., Sherman, Mara H., Zhang, Li, Kremer, Daniel, Hwang, Rosa F., Witkiewicz, Agnes K., Ying, Haoqiang, Asara, John M., Evans, Ronald M., Cantley, Lewis C., Lyssiotis, Costas A., Kimmelman, Alec C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5228623/
https://ncbi.nlm.nih.gov/pubmed/27509858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19084
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