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DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer
BACKGROUND: Prostate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We hypothesized that metastatic, castration-resistant prostate cancers with DNA-repair defects would respond to poly(adenosine diphosphate [ADP]–ribose) polymerase (PARP) inhibit...
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| Publicado no: | N Engl J Med |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5228595/ https://ncbi.nlm.nih.gov/pubmed/26510020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1506859 |
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