Combined Inhibition of the Renin-Angiotensin System and Neprilysin Positively Influences Complex Mitochondrial Adaptations in Progressive Experimental Heart Failure

BACKGROUND: Inhibitors of the renin angiotensin system and neprilysin (RAS-/NEP-inhibitors) proved to be extraordinarily beneficial in systolic heart failure. Furthermore, compelling evidence exists that impaired mitochondrial pathways are causatively involved in progressive left ventricular (LV) dy...

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Veröffentlicht in:PLoS One
Hauptverfasser: Grois, Laura, Hupf, Julian, Reinders, Jörg, Schröder, Josef, Dietl, Alexander, Schmid, Peter M., Jungbauer, Carsten, Resch, Markus, Maier, Lars S., Luchner, Andreas, Birner, Christoph
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226780/
https://ncbi.nlm.nih.gov/pubmed/28076404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169743
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