Cetuximab response in CRC patient-derived xenografts seems predicted by an expression based RAS pathway signature

Cetuximab is an approved treatment for metastatic colorectal carcinoma (mCRC) with codon 12/13-KRAS mutations, recently questioned for its validity, and alternative mutation-based biomarkers were proposed. We set out to investigate whether an expression signature can also predict response by utilizi...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Guo, Sheng, Chen, Dawei, Huang, Xuesong, Cai, Jie, Wery, Jean-Pierre, Li, Qi-Xiang
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226604/
https://ncbi.nlm.nih.gov/pubmed/27409671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10499
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