Stress-induced phosphoprotein-1 maintains the stability of JAK2 in cancer cells

Overexpression of stress-induced phosphoprotein 1 (STIP1) − a co-chaperone of heat shock protein (HSP) 70/HSP90 – and activation of the JAK2-STAT3 pathway occur in several tumors. Combined treatment with a HSP90 inhibitor and a JAK2 inhibitor exert synergistic anti-cancer effects. Here, we show that...

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Vydáno v:Oncotarget
Hlavní autoři: Tsai, Chia-Lung, Chao, Angel, Jung, Shih-Ming, Tsai, Chi-Neu, Lin, Chiao-Yun, Chen, Shun-Hua, Sue, Shih-Che, Wang, Tzu-Hao, Wang, Hsin-Shih, Lai, Chyong-Huey
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226602/
https://ncbi.nlm.nih.gov/pubmed/27409672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10500
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