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Stress-induced phosphoprotein-1 maintains the stability of JAK2 in cancer cells
Overexpression of stress-induced phosphoprotein 1 (STIP1) − a co-chaperone of heat shock protein (HSP) 70/HSP90 – and activation of the JAK2-STAT3 pathway occur in several tumors. Combined treatment with a HSP90 inhibitor and a JAK2 inhibitor exert synergistic anti-cancer effects. Here, we show that...
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Publicado no: | Oncotarget |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Impact Journals LLC
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5226602/ https://ncbi.nlm.nih.gov/pubmed/27409672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10500 |
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