Acquired nintedanib resistance in FGFR1-driven small cell lung cancer: role of endothelin-A receptor-activated ABCB1 expression

Genomically amplified fibroblast growth factor receptor 1 (FGFR1) is an oncogenic driver in defined lung cancer subgroups and predicts sensibility against FGFR1 inhibitors in this patient cohort. The FGFR inhibitor nintedanib has recently been approved for treatment of lung adenocarcinoma and is cur...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Englinger, Bernhard, Lötsch, Daniela, Pirker, Christine, Mohr, Thomas, van Schoonhoven, Sushilla, Boidol, Bernd, Lardeau, Charles-Hugues, Spitzwieser, Melanie, Szabó, Pál, Heffeter, Petra, Lang, Irene, Cichna-Markl, Margit, Grasl-Kraupp, Bettina, Marian, Brigitte, Grusch, Michael, Kubicek, Stefan, Szakács, Gergely, Berger, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226575/
https://ncbi.nlm.nih.gov/pubmed/27367030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10324
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