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Biased small‐molecule ligands for selective inhibition of HIV‐1 cell entry via CCR5

Since the discovery of HIV's use of CCR5 as the primary coreceptor in fusion, the focus on developing small‐molecule receptor antagonists for inhibition hereof has only resulted in one single drug, Maraviroc. We therefore investigated the possibility of using small‐molecule CCR5 agonists as HIV...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Berg, Christian, Spiess, Katja, Lüttichau, Hans R., Rosenkilde, Mette M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226280/
https://ncbi.nlm.nih.gov/pubmed/28097000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.262
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