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Treatment effect heterogeneity for univariate subgroups in clinical trials: Shrinkage, standardization, or else
Treatment effect heterogeneity is a well-recognized phenomenon in randomized controlled clinical trials. In this paper, we discuss subgroup analyses with prespecified subgroups of clinical or biological importance. We explore various alternatives to the naive (the traditional univariate) subgroup an...
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| Udgivet i: | Biom J |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5226126/ https://ncbi.nlm.nih.gov/pubmed/26485117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.201400102 |
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