Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications

Conventional in vitro human hepatic models for drug testing are based on the use of standard cell lines derived from hepatomas or primary human hepatocytes (PHHs). Limited availability, interdonor functional variability and early phenotypic alterations in PHHs restrict their use, whilst standard cel...

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Detalhes bibliográficos
Publicado no:Basic Clin Pharmacol Toxicol
Main Authors: Nelson, Leonard J., Morgan, Katie, Treskes, Philipp, Samuel, Kay, Henderson, Catherine J., LeBled, Claire, Homer, Natalie, Grant, M. Helen, Hayes, Peter C., Plevris, John N.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225883/
https://ncbi.nlm.nih.gov/pubmed/27285124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcpt.12631
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